GTP

Above – phosphorylation of GDP (left) yields GTP (right), which is hydrolysed back to GDP by GTPases.

GTP is generated in the citric acid cycle, and is an important energy molecule. GTP is most important in its role as a molecular switch in signal transduction.

GTPases hydrolyze GTP to GDP + Pi in the highly conserved domains of G-proteins, which are associated with GPCRs (guanine nucleotide-binding protein-coupled receptors, G-protein coupled receptors, serpentine receptors, 7TM receptors, or heptahelical receptors).

Above GTP